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The REDEFINE 1 trial utilized a flexible protocol, permitting participants to adjust their dosages during the study

While preclinical rodent studies identified thyroid C-cell tumors, leading to FDA boxed warnings, no established causal link exists between tirzepatide use and increased cancer risk in humans

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In patients with continuous/atypical facial pain, results are less predictable, so therapy is individualized and often begins with an optimized medication plan (dosing, combinations, sequencing)