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doi: 10.1016/j.humimm.2009.02.008

Fulghesu AM et al

Such toxicity can be minimised by an assessment of the riskbenefit balance for the individual to be treated

Once cardiomyocytes are subjected to intolerable hypoxic stress or other factors, irreversible mitochondrial damage will result, which in turn leads to mitochondrial swelling, deformation, and rupture, thus directly affecting mitochondrial energy metabolism