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This binding initiates cascade reactions that ultimately produce the desired therapeutic effect

The activation of two transcription factors, aryl hydrocarbon receptor (AhR, which is sensitive to ROS) and hypoxia-inducible factor (HIF)-1, which is responsive to the TCA metabolites succinate, were associated with an increase in IL-22 production

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A dihydroartemisinin-loaded nanoreactor motivates anti-cancer immunotherapy by synergy-induced ferroptosis to activate Cgas/STING for reprogramming of macrophage