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2023;72(3):doi:10.1099/jmm.0.001670 49

Allergic reactions to B12 supplements are extremely uncommon but have been reported, typically manifesting as skin rash or itching

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Epidemiology demographics middle-aged females (9:1) body location most commonly involves the 3rd and 4th interdigital nerves between the metatarsal heads (3rd webspace) Etiology Pathophysiology mechanism of injury not fully understood compression/tension of the interdigital nerve around the transverse intermetatarsal ligament repetitive microtrauma pathoanatomy perineural fibrosis and entrapment of the interdigital nerve Anatomy Interdigital nerve location lies plantar to the transverse intermetatarsal ligament between the metatarsal heads confluence branches of the lateral and medial plantar nerves Presentation Symptoms pain worse with weight-bearing or wearing narrow toe box shoes (e.g