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The study population was recruited from a single center, which may limit the generalizability of our findings

Theres limited data on compounded semaglutide, as its not FDA-approved, so its effectiveness is not well-studied in clinical trials

In addition, genetic defects in folate metabolism and its transport can cause megaloblastic anemia and a variety of neurological disorders, including developmental delays, intellectual disability, seizures, and ataxia, underscoring the vital role of folate in brain development and function during both fetal and postnatal stages [28, 29]

Plozasiran is already approved as Redemplo in the US, EU, China, Australia, and Canada for familial chylomicronemia syndrome

In brief, exosome pellets were resuspended in 100 l of 50 mM Tris-HCl (pH 8.0) and incubated with 100 L of the Amplex Red reagent containing 2 U/mL HRP, 0.2 U/mL choline oxidase, and 100 M acetylcholine in a final volume of 200 L