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To determine the tolerable upper intake level (UL), the FNB selected adverse reproductive effects in rats as the most sensitive index of toxicity and applied a large uncertainty factor because animal data were used (2)

After one week, these devices were wirelessly controlled using a radio-frequency power source to activate cholinergic terminals in the small intestine with a 473 nm laser (25 mW, 50 Hz)

Acknowledgements This work was supported by the Intramural Research Program of the NIH/National Institute of Environmental Health Sciences 1Z01ES090079

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The Phase 2 trial published in the New England Journal of Medicine studied doses ranging from 1mg to 12mg weekly