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According to the FDA's press release it agreed to approve the drug for obesity based on three randomised, double-blind, placebo-controlled trials during which more than 2,600 patients received Wegovy for up to 68 weeks and more than 1,500 patients received placebo (US FDA 2021)

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Screening of non-syndromic early-onset child and adolescent obese patients in terms of LEP, LEPR, MC4R and POMC gene variants by next-generation sequencing

Applichem GmbH, Germany) and 1% BSA in PBS, for 30 min at 4 C, and were immediately scraped into lysis buffer, to reveal the endocytosed pool of molecules