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177,178 Mutations in ZIP4 can lead to acrodermatitis enteropathica, a rare autosomal recessive metabolic disorder characterized by ZD, commonly observed in infants

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Clin Endocrinol (Oxf) 91:3340

In one embodiment, a pharmaceutical composition is provided that contains: about 0.25% to about 10% of a reducing agent-choline ester, optionally, about 0.05% to about 1.0% of a biochemical energy source, about 0.25% to about 1% buffer, about 0.2% to about 0.6% tonicity agent, and about 0.1% to about 0.4% viscosity agent

15 In AD, there is a reduction in the conversion of proNGF to mature NGF and an enhancement in the degradation of mature NGF, 344 leading to a deficiency in mature NGF and accumulation of proNGF in the brain