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Acknowledgments The authors would like to thank the Core Facilities Sharing Platform for Life and Environment Sciences of Shandong University, including Cheng-Jia Zhang and Nan-Nan Dong for providing the bacteriological incubator and Zhi-Feng Li for RT-qPCR instruction

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Astrocytes acquire iron via the divalent metal transporter 1 (DMT1) pathway, while ceruloplasmin located on the astrocyte membrane effectively inhibits lipid peroxidation and ferroptosis through protein-protein interactions or regulating the oxidation of Fe 2+ to Fe 3+ (Jeong and David, 2003)

RBCs (20 L) were incubated with 1% Triton X-100 PBS, and varying concentrations of PDA@Pt (0, 10, 20, 40, 80, 160, and 320 g/mL) at 37 C for 3 h