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Lonza) was used for all other KAT6A mutations to increase the rate of HDR, following a modified Alt-R CRISPR-Cas9 System protocol (IDT)

Key findings from this review demonstrate that metabolic disturbances, particularly those affecting carbohydrate, amino acid, and lipid metabolism, play critical roles in amplifying inflammation and oxidative stress, underscoring the potential of metabolic-targeted therapies to improve patient outcomes