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TOR complex 2-Ypk1 signaling is an essential positive regulator of the general amino acid control response and autophagy

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Compared with vehicle-treated obese mice, the treated animals showed reductions in body-weight measures, white-adipose mass and adipocyte size

Since DNA damage induced by the drugs cannot be repaired, the various cell death modalities including not only apoptosis but also autophagy, necroptosis and ferroptosis, are induced