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These include a high mutation rate of viruses, the propensity for developing resistance, a wide variety of viral types with few commonalities, and difficulties in balancing drug efficacy with safety during the research and development process

Additionally, some medications, such as acetaminophen (paracetamol), can also strain glutathione reserves

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In an experiment with mouse ovaries, treatment with antioxidant pyrroloquinoline quinone efficiently decreased ROS production, alleviated oxidative stress, relieved mtDNA damage, and increased ATP production