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However, consumption of any type of vegetarian diet dramatically increases the prevalence of vitamin B 12 deficiency in individuals across all age groups (127, 128)

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Although CHKs did not show differential expression at 24 hours post-treatment, it is plausible that such changes may manifest at later timepoints subsequent to RRM2 downregulation

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Studies have found that high NNMT expression promotes the release of inflammatory factors in adipose tissue, and NNMTi can effectively alleviate adipose inflammation and improve the microenvironment by inhibiting NNMT