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The adhesion molecules may initiate the inflammatory process by activating the release of proinflammatory cytokines and chemokines [207]

This highlights the functional consequences of earlier molecular lesions and reinforces the pivotal role of Increased proliferation and Decreased apoptosis as central KEs in lung cancer initiation within the AOPN framework

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Control of the eIF4E activity: structural insights and pharmacological implications

For instance, metformin can activate SIRT1 and regulate related pathways to mitigate LPS-induced SAKI and improve renal function of HFD-/STZ-induced diabetic rats (Xu et al., 2020