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3.4 Simulation of Pharmacokinetics and IGF-I Figure 4 presents the simulated steady-state exposureresponse between steady-state average GH pharmacokinetics and IGF-I average SDS for once-daily subcutaneous administration of GH in children and adults with GHD, together with the steady-state GH concentration and IGF-I SDS time-course profiles

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The enteric nervous system (ENS), often called the 'second brain,' controls peristalsis through a network of neurons embedded in the intestinal wall

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