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J Affect Disord (2013) 150:72735.10.1016/j.jad.2013.05.083 95 BlumbergHPKrystalJHBansalRMartinADziuraJDurkinKet alAge, rapid-cycling, and pharmacotherapy effects on ventral prefrontal cortex in bipolar disorder: a cross-sectional study

However, trials of single antioxidant supplements for extending lifespan in humans have largely been disappointing

One of these mechanisms is through the activation of transcription factors, such as nuclear factor erythroid 2 (NRF2), which promotes the expression of genes involved in oxidative stress response