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Asia Pac J Clin Nutr 25(2):221226

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While conventional curcumin has demonstrated a favorable safety profile at doses up to 8,000 mg/day (242), hepatotoxic events have been reported at significantly lower doses when co-administered with absorption enhancers such as piperine

The disorder usually presents in early childhood and is characterized by episodes of hypoketotic hypoglycemia (that can cause encephalopathy), hepatomegaly, elevated liver enzymes (transaminases), and hypoammonemia in infants