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IGF-I gene defects result in mental retardation and severe fetal and postnatal growth failure with GH hypersecretion and marked insulin resistance

Parkinsonism Relat Disord 16(1):5759 Bast A, Erttmann SF, Walther R, Steinmetz I (2010) Influence of iNOS and COX on peroxiredoxin gene expression in primary macrophages

However, some adults with pre-existing cardiovascular disease, diabetes, or significant kidney disease may not tolerate aggressive blood pressure control