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Of the 164 trials, 34% (N = 56) assess disease-modifying biological agents, 41% (N = 68) test disease-modifying small molecule drugs, 10% (N = 17) evaluate cognitive enhancing agents, and 14% (N = 23) test drugs for the treatment of neuropsychiatric symptoms

FDA is also asking that ARS submit additional information on testing for nitrosamine impurities based on new draft guidance that was issued after neffys New Drug Application was submitted in October 2022