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For instance, renally eliminated drugs such as digoxin, metformin, gabapentin, and direct oral anticoagulants frequently require dose reduction or avoidance when creatinine clearance falls below specific thresholds (Pazan et al., 2022)

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After single IM administrations of doses 20, 100, or 500 g/kg, the peak time (T max ) of each dose was 3 min