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The expression and purification of mt-hNNMT was modified from a previously reported protocol

GSOR is then cleaved into GSSG and ROH by a second nucleophilic substitution by the GSH molecule according to a mechanism that is not yet fully elucidated (Deponte, 2013)

However, in guidelines published in 2012, the British Columbia Medical Association (Canadian Ministry of Health) recommended a dose of 1000 g/day for pernicious anemia or food-bound cobalamin malabsorption [34]