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Although Pioglitazone was initially thought to act only as a direct transcriptional regulation of the PPAR nuclear receptor, later data revealed that it also binds to mitochondrial membranes ( Studies conducted in multiple cell types demonstrated that TZDs inhibit mitochondrial pyruvate carrier (MPC) activity by direct binding (Buchanan and Taylor, 2020), which may mediate some of the beneficial effects of PGZ a variety of diseases including vitiligo

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Cancer 117(5):982-91, 2011

13 C-isotopologue analysis Mtb strains were grown in standard 7H9 media to late log phase (OD 600 = 0.81) before being washed and resuspended in 13 C-labelled media and incubated for 48 h

Krause, I, et al., Brief report: immune factors in autism: a critical review