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This supports a role of c-MET activation in tumour invasive front in the tumour progression and invasion involving FAK and AKT downstream

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Since NF-kB is also associated with chemotherapy resistance and radioresistance, loss of therapy sensitivity cannot be excluded

A major component of the evidence that implicates lipids in AD pathogenesis is the presence of the APOE 4 genetic allele, which represents the highest genetic risk factor for late-onset AD (281283)

All of these transcriptional effects collectively create a TME optimal for glioma expansion, not only by fueling metabolic needs but also by orchestrating the structural and immunological landscape around the tumor allowing it to thrive ( Figure 4 )