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In another study by Hurley et al., iLBD cases had an increased number of IBA1-positive microglia

As the HPT axis has long been involved in the research of depression (106), it is reasonable to believe that the dysfunction of the HPT axis in GD, with its effect of disrupting neurotransmitter metabolism, inducing oxidative stress, contributing to other complications and so forth, has a potentially vital effect on the development of depression

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These metabolites may indirectly influence lipid peroxidation through their involvement in antioxidant defense or signal transduction pathways (Figure 13)

For actin nucleation and elongation of unbranched actin filaments Cpn secretes within the first 15 min of infection the soluble effector protein CPn0572, which belongs to the TarP protein family 45