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The effects of butyrate on NAFLD risk factors The effects of butyrate on obesity-induced NAFLD A growing body of evidence suggests that butyrate is distributed beyond the gut to the central nervous system and peripheral tissues, including white and brown adipose tissue, which regulates whole-body energy metabolism, substrate metabolism and the development of NAFLD in animal models ( Butyrate and lipid metabolism disorders Dyslipidaemia appears to significantly influence the development and progression of the metabolic disorders associated with NAFLD ( Butyrate can attenuate hypercholesterolemia by downregulating the expression of crucial genes for the biosynthesis pathway of cholesterol in the intestine (78)

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