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Vitexin can not only suppress de novo lipogenesis but also enhance fatty acid oxidation and lipolysis, in addition, it can improve insulin signaling in HFD mice possibly through binding to leptin receptor and activating AMPK [33, 34]

Mechanistically, -Syn oligomers interact with mitochondrial respiratory chain complex I, impairing its function, leading to mitochondrial membrane potential depolarization, and promoting the release of proapoptotic factors into the cytoplasm

There is documentation of nicotine-induced inhibition of myofibroblast differentiation in human gingival fibroblasts in vitro 46

This partly explains the higher morbidity and mortality rates observed in COVID-19 patients with preexisting diabetes 307

10.1016/j.arr.2021.101364 105 MajumderP.HsuT