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Doses vary from 1,000 to 4,500 mg per day

Psychiatry 87 , 144148 (2016)

This dysfunction is partly due to myofascial trigger points (painful muscle knots)

Ann Gastroenterol

TNF released by Kupffer cells is thought to play a key role in exacerbating liver damage, primarily by causing hepatocyte death but also by degrading the hepatic microcirculation by causing endothelial cells to swell and become activated, which leads to sinusoidal platelet aggregation and makes it easier for peripheral immune cells to enter