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Targeted agents like 5-HT4 agonists (tegaserod, prucalopride), guanylate cyclase-C agonists (linaclotide), and NHE3 inhibitors (tenapanor) modulate motility and pain signaling but face limitations such as side effects (e.g., diarrhea, cardiovascular risks) or insufficient long-term data

In the case of TRIM5, the spatial arrangement of TRIM5 dimers scaffolded on a retroviral core allows the RING domain of one TRIM5 molecule to poly-ubiquitylate the RING domain on another TRIM5 molecule (Mandell et al., 2016)

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