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Description

Oral sulforaphane increases Phase II antioxidant enzymes in the human upper airway

A., & Imai, S

doi: 10.1055/s-0031-1299949 7 AltschulerE

The underlying mechanisms are downregulation of SLC7A11 which reduces glutathione production, as well as upregulation of ACSL4, which stimulates accumulation of PUFAs-containing phospholipids

By binding to the Keap1 chaperone protein, sulforaphane forces the release of Nrf2, allowing it to flood the nucleus and bind to the Antioxidant Response Element (ARE)