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Although it is well known that metformin induces cellular energy depletion and a concomitant activation of AMP-activated protein kinase (AMPK) through inhibition of the respiratory chain, previous studies have shown inconsistent results with regard to the action of metformin on pancreatic -cells

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Handling This compound should be handled using appropriate laboratory safety procedures by trained professionals in a controlled research environment

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GSH deficiency makes cells more sensitive to oxidative stress and can cause degeneration of epithelial cells 50 , 51