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10.1016/j.clnesp.2023.12.150 76

In: Clinical applications of biomolecules in disease diagnosis: a comprehensive guide to biochemistry and metabolism

Reduced p27Kip-1 levels, often due to overexpression of the F-box protein Skp2, are associated with tumor progression and poor prognosis in various cancers

However, Treg cells inhibit immune responses by secreting IL-10 and TGF- and can directly interact with effector T cells to suppress the activity of antitumor immune cells, aiding tumor cells in evading immune surveillance and attack (79)