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Labial Lentigo (labial melanotic macule) Cancer Therapy Advisor Intra oral photograph of the lesion, melanotic macule as well as the Download Scientific Diagram Pigmented macule on the mandibular gingiva (a, case 1), affecting the Download Scientific Diagram Smokers melanosis . Oral pigmentation seen in heavy smokers . Investigations have shown ability of melanin to bind to noxious substances. . Exposure to polycyclic amines ( Nicotine & benzpyrene) has shown melanotic macule gums Differential Diagnosis of Pigmented Lesions in the Oral Mucosa: A Clinical Based Overview
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