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As the most enriched PCD process in GBM, ferroptosis induces immunosuppression

doi: 10.1517/14712598.3.1.127

In vitro and in vivo studies in animals have shown that the use of deuterated PUFAs can lower the peroxidation effects on producing atherosclerosis, control hyperlipidaemia, and reduce cholesterol levels in blood ( Although these are beneficial signals for human health, many questions are raised for the whole of the organisms health since the deuterated lipids will accumulate in a vast number of cells and in their membranes, as in the case of myelin, and will cause a significant alteration in the metabolism of the deuterated host organism (Torres et al., 2021)

Both local application (directly at the injury) and systemic intramuscular injection proved effective

The dose and method of cisplatin administration are the primary factors that determine the effectiveness of the cisplatin-induced AKI model, but the sensitivity to cisplatin may vary among animal strains