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Aloe-emodin alleviates doxorubicin-induced cardiotoxicity via inhibition of ferroptosis

These include tumor protein p53, cyclin-dependent kinase inhibitor 2A, phosphatase and tensin homolog, retinoblastoma, hypoxia-inducible factors, and matrix metalloproteinases (MMPs), among others [711]

Wu et al., 1998, 1999)

The characteristic morphological changes observed in ferroptosis primarily include mitochondrial atrophy, a ruptured outer membrane, reduced cristae, a compressed inner membrane and intact nuclei (196)

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