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The iron chelator DFO retards photoreceptor degeneration in animal models of RP, supporting a role for ferroptosis in RP progression (244)

Concluding Remarks The multilayered functional interactions of the mTOR signaling pathways and the process of autophagy are deciphered to a great extent at the cellular level, but we still have an incomplete understanding of their integration at the physiopathological level

References Pallesen J, Wang N, Corbett KS, Wrapp D, Kirchdoerfer RN, Turner HL, et al

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Genetic variants that impact the carboxyl-terminal domain of FTL and modify its iron-binding capacity have been linked to the disease hereditary neuroferritinopathy, it is characterized by progressive neurologic symptoms and iron accumulation, particularly in the basal ganglia