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These include the reported role of CUL4A-mediated degradation of p27 in cell proliferation in the early stages of erythropoiesis and cell cycle exit at a later stage of erythropoiesis.87 A recent, exciting study demonstrated that UBE2O remodels the proteome during terminal erythroid differentiation, underscoring the importance of the UPS in erythropoiesis.9 Ubiquitination is a dynamic and reversible process.10 It has been reported that deubiquitylases are capable of removing ubiquitin from their protein substrates and allow proteins to be salvaged from proteasomal degradation.11 USP7 is a deubiquitylase that belongs to the ubiquitin-specific protease (USP) family, which constitutes the largest subgroup of deubiquitylases

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Kugel, A