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The structural change of brain is progressively developed before onset in the ultra-high risk (UHR) for psychosis subjects, during late adolescence or early adulthood, and continuous through the lifespan of the patients [9,10,11,12,13,14]

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Then, genes with the top 30% highest value of betweenness centrality (BC) in the subnetwork were identified as key target genes and formed the core PPI network

Endogenous interleukin 18 suppresses hyperglycemia and hyperinsulinemia during the acute phase of endotoxemia in mice