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Pulse amplitude and frequency drive downstream IGF-1 synthesis, drive lipolysis, determine anabolic signaling in muscle and bone

Common Side Effects When side effects occurred, they were typically mild, transient, and similar in frequency to placebo groups: Reported Adverse Effects Most Common (occurring in small percentage of participants): Mild to moderate headaches (most frequently reported, often resolving with continued use) Injection site reactions (minor redness, swelling, or irritation at injection site) Gastrointestinal effects (particularly at higher oral doses: mild nausea, diarrhea, flatulence) Fatigue (reported occasionally during initial adaptation period) Rare Events: One case of chest tightness was deemed possibly related to treatment in safety trials

injection and CTP modification facilitated the specific targeting of the CaP nanoparticles to the failing heart, which may reduce nanoparticle accumulation in other major organs

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