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Heffernan M, Summers RJ, Thorburn A, et al

Vitamin B12: Consumer Fact Sheet

Post-hoc analyses from clinical trials show tirzepatide may reduce high-sensitivity C-reactive protein (hsCRP) levels, though reductions appear to correlate with weight loss and improved glycemic control

B12 supplementation has been reported to help with fatigue and nausea that semaglutide users commonly experience, though the evidence for this is largely anecdotal rather than clinical