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Recent evidence suggests that PEGylation is generally employed to increase molecular weight and protect the payloads and/or drug nanoparticles from proteolytic degradation (Harris and Chess, 2003), thereby expanding their applicability in Alzheimer's and enabling specific designs that (i) prolong circulation timeas PEG chain can mitigate a rapid uptake by the RES (Kong et al., 2020), (ii) play a role in physical stabilityby reducing particle agglomeration and/or protein corona effect (Guerrini et al., 2018) or providing a steric stability with targeted A aggregates (Singh et al., 2022), (iii) improve BBB penetration (Kochman et al., 2026), and (v) enable controlled drug release and improved pharmacokinetics (Turjeman et al., 2015)
This effect in turn lowers the risk of endotoxemia, which ultimately alleviates secondary liver inflammation and tissue injury
Abdullah B, Periasamy C, Ismail R
To assess dose- dependent BG inhibition, we used a 12-point, two-fold dilution: BG036 61-352 (4.4 0.002 M), BG044 (4.40.002 M), BG032 (8.80.004 M), and BG038 (8.80.004 M)
