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On the other hand, flavonoids like kaempferol and diosmin exhibit beneficial effects in lung fibrosis but do not directly act via NLRP3 inhibition

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This proposed mechanism of action is via mitochondrial dysfunction and increased O 2 production in granulosa cells, leading to ferroptosis, a form of programmed cell death characterized by lipid peroxidation and iron accumulation [60]

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The key transcription factors that regulate gene expression are NF-E2-related factor 2 (Nrf2) via the antioxidant response element (ARE), AP-1, and nuclear factor kappa B (NF-B)

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Often paired with CJC-1295 in synergistic research

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Song and Dityatev, 2018)

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