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As for the role that caffeine has in the purported benefits of the coffee enema, drinking coffee is a far more effective method for increasing the amount of caffeine in your blood (and hence causing vasodilation to potentially send toxins from the blood into the colon, or causing increased bile acid secretion to potentially facilitate liver detoxification) compared to administering it at the other end

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In particular, the copolymer (C-2) in the second coating may consist of methacrylic acid repeating units and methyl methacrylate repeating units

Valavanidis A, Vlachogianni T, Fiotakis C (2009) 8-hydroxy-2 -deoxyguanosine (8-OHdG): a critical biomarker of oxidative stress and carcinogenesis

Heatshock proteins act as " molecular chaperones they protect, transport and assist with the refolding of damaged proteins