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In 2003, a Cochrane review of three RCTs on cognitive function in patients with AD or other forms of cognitive impairment also found no evidence of benefits of B12 on cognitive function compared with placebo

doi: 10.1093/sleep/11.5.425 19 VerrilloEBizzarriCBruniOFerriRPavoneMCappaMet al

B vitamins are water-soluble micronutrients that the body cannot store in large amounts, so a regular dietary supply is essential

Informed, written consent was provided by all participants or their surrogates before trial commencement