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Clinical trials used doses as high as 1 mg per day without safety concerns, but 300 mcg is the most commonly referenced dose in peptide medicine literature and in the investigational protocols that have been published since the formal trials concluded

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A deficiency in Vitamin B12 may lead to fatigue, problems with balance, depression, confusion, poor memory, infertility, pale skin, heart palpitations, nerve problems, and damage to the nervous system

Inhaled anticholinergic bronchodilators include ipratropium and tiotropium (1)(3)