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Effects of Astragaloside IV on heart failure in rats

10.1124/jpet.104.065524 86 Rodrguez de FonsecaF.Del ArcoI.Bermudez-SilvaF.BilbaoA.CippitelliA.NavarroM

After 12 h, 50, 100 or 200 M of NIE or NIB was added to each well and the plates were incubated for 6, 12 and 24 h at 37C

Simultaneously, its enhancement of NRF2-mediated antioxidant defenses confers resistance to oxidative-stress-induced neuronal apoptosis, which is a major contributor to cognitive decline