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2 The main sources of cellular ROS are mitochondria and nicotinamide adenine dinucleotide phosphate (NADPH) oxidases, and peroxisomes containing xanthine oxidase and the inducible form of nitric oxide synthase, which produce superoxide anion and nitric oxide, respectively

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This makes oral and parenteral administration of exogenous GSH problematic as it leads to poor accumulation in the CNS (Ronaldson and Davis, 2015)

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