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In addition, in terms of the prodrug approach, not all drugs can be conjugated with the promoiety to be recognized as a substrate of the transporter due to the difficulties in synthesis implementation or limits of the chemical structures of the compounds

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The pineal gland is the first endocrine gland that is formed in the embrional phase

This culture method promoted proliferation and enabled propagation of several patient-derived pLGG cells for up to 1 month ex vivo ( 4 In vivo models of pLGG 4.1 Generating non-NF1 pLGG xenograft models for preclinical drug testing One of the ultimate goals for developing pLGG mouse models is for preclinical drug testing