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Layered onto these genomic and signalling defects are epigenetic derangements that lock the ovary into a pathologic state

10.1016/j.cbpc.2021.109151 101 WangX.WangR.XingD.SuH.MaC.DingY.et al (2005)

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The higher proton leak may give a hint at mitochondrial adaptation to protect the cells from the formation of reactive oxygen species (ROS), potentially induced by a higher electron flux (49)