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Data from the simultaneous measurement of extracellular acidification and oxygen consumption revealed that in glucose-fed human iPSC-derived astrocytes glycolysis and oxidative phosphorylation contribute both around 50% to the ATP regeneration and that accelerated glycolysis can compensate for an impairment of mitochondrial ATP regeneration [122]

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The trade-off is local side effects that injections do not cause: mouth irritation, taste disturbances, tongue numbness, and throat irritation

Mice were monitored daily, and clinical scoring was performed as mentioned before with a 6-point scaling system

Mol Med Rep 8:737740