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Yao, S.-Q

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FIGURE 3 Both Nqo1 Antisense Transcript 1 and Nqo1 mRNA Expressions Are Associated With Cigarette Smoke Extract Concentration and Duration in Mle-12 Cells Given that CS exposure was closely associated with the expression levels of Nqo1-AS1 (or its human homologue) and Nqo1 mRNA in lung tissues of mouse or PBMCs from patients with COPD, we speculated that CSE might have effects on the expression levels of Nqo1-AS1 and Nqo1 in vitro

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7,40 While the activation of ALOX12 exacerbates the liver inflammatory response and cell death by producing 12-HETE, which directly binds to GPR31 and induces subsequent MAPK signaling, 40 the increase in ALOX12 expression in cardiomyocytes promotes myocardial damage through 12-HETE-induced inflammation and, more importantly, by directly enhancing NEDD4-mediated TAK1 (transforming growth factor-activated kinase 1) degradation in an enzymatic activityindependent manner